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Journal of Water and Health Vol 08 No 2 pp 299–310 © IWA Publishing 2010 doi:10.2166/wh.2009.184

A Cryptosporidium hominis outbreak in North-West Wales associated with low oocyst counts in treated drinking water

B. W. Mason, R. M. Chalmers, D. Carnicer-Pont and D. P. Casemore

Communicable Disease Surveillance Centre, Temple of Peace and Health, Cathays Park, Cardiff, UK Tel.: +44(0)2920 402471 Fax: +44(0)2920 402560 E-mail: Brendan.mason@nphs.wales.nhs.uk
UK Cryptosporidium Reference Unit, NPHS Microbiology Swansea, Singleton Hospital, Swansea, UK
Health Protection Team, National Public Health Service for Wales, Preswylfa, Hendy Road, Mold, UK
Centre for Research into Environment and Health, University of Wales, Aberystwyth, UK


ABSTRACT

An outbreak in the autumn of 2005 resulted in 218 confirmed cases of Cryptosporidium hominis. The attack rate (relative risk 4.1, 95%CI 2.8–9.1) was significantly higher in the population supplied by Cwellyn Water Treatment Works (WTW). A case–control study demonstrated a statistically significant association (odds ratio 6.1, 95% CI 1.8–23.8) between drinking unboiled tap water and C. hominis infection. The association remained significant in a logistic regression analysis, with an adjusted odds ratio of 1.30 (95 CI 1.05–1.61) per glass of unboiled tap water consumed per day. This evidence together with environmental and associated microbiological investigations, and the absence of effective treatment to remove Cryptosporidium oocysts at the WTW, led to the conclusion that the outbreak was waterborne. Oocyst counts in final treated water at the WTW and at different points in the distribution system were consistently very low, maximum count in continuous monitoring 0.08 oocysts per 10 litres. Data from continuous monitoring and the epidemic curve is consistent with the hypothesis that low numbers of oocysts of C hominis were present in treated water continuously during the outbreak and these were of sufficient infectivity to cause illness. All surface water derived water supplies present a potential risk to human health and appropriate control measures should be in place to minimise these risks.

Keywords: case–control study; Cryptosporidium hominis; low oocyst counts; molecular methods; outbreak management; waterborne outbreak


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